Thalidomide-O-amido-PEG4-C2-NH2 is an engineered E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand combined with a PEG4 linker. This compound is designed to facilitate targeted protein degradation via PROTAC (Proteolysis Targeting Chimera) technology, enabling the selective modulation of protein levels in cellular systems. Its applications include studying protein degradation pathways and developing therapeutic strategies that leverage the ubiquitin-proteasome system for enhanced drug efficacy.
Thalidomide-O-amido-PEG4-C2-NH2 is an engineered E3 ligase ligand-linker conjugate that features a thalidomide-derived cereblon ligand combined with a PEG4 linker. This compound is designed to facilitate targeted protein degradation via PROTAC (Proteolysis Targeting Chimera) technology, enabling the selective modulation of protein levels in cellular systems. Its applications include studying protein degradation pathways and developing therapeutic strategies that leverage the ubiquitin-proteasome system for enhanced drug efficacy.
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