Thalidomide-O-C3-azide is a modified form of the cereblon (CRBN) inhibitor, Thalidomide, featuring an azide group that enables efficient insertion into click chemistry reactions. This compound undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, making it a valuable tool for the synthesis of E3 ubiquitin ligase ligand-linker conjugates. Thalidomide-O-C3-azide is primarily utilized in the development of PROTACs, facilitating targeted protein degradation studies and advancing research in cellular signaling and therapeutic applications.
Thalidomide-O-C3-azide is a modified form of the cereblon (CRBN) inhibitor, Thalidomide, featuring an azide group that enables efficient insertion into click chemistry reactions. This compound undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, making it a valuable tool for the synthesis of E3 ubiquitin ligase ligand-linker conjugates. Thalidomide-O-C3-azide is primarily utilized in the development of PROTACs, facilitating targeted protein degradation studies and advancing research in cellular signaling and therapeutic applications.
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