Thalidomide-O-PEG5-tosyl is an E3 ligase ligand-linker conjugate that utilizes a Thalidomide-derived cereblon ligand in combination with a 4-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC technology, facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. Thalidomide-O-PEG5-tosyl demonstrates reactivity with nucleophiles, including amine and hydroxy-containing molecules, making it a valuable tool for researchers studying targeted protein degradation and related pathways.
Thalidomide-O-PEG5-tosyl is an E3 ligase ligand-linker conjugate that utilizes a Thalidomide-derived cereblon ligand in combination with a 4-unit polyethylene glycol (PEG) linker. This compound is designed for use in PROTAC technology, facilitating the recruitment of E3 ligases to target proteins for ubiquitination and subsequent degradation. Thalidomide-O-PEG5-tosyl demonstrates reactivity with nucleophiles, including amine and hydroxy-containing molecules, making it a valuable tool for researchers studying targeted protein degradation and related pathways.
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