Thalidomide-Piperazine-Piperidine

Catalog No.: A31564
E3 Ligase Ligand-Linker Conjugates
Thalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that targets cereblon, a key component in the ubiquitin-proteasome system. This compound incorporates a Thalidomide-based ligand and a piperazine-piperidine linker, making it suitable for use in PROTAC (proteolysis-targeting chimeras) technology. Its design facilitates targeted degradation of specific proteins, providing valuable insight into protein regulation and function in various biological contexts. Thalidomide-Piperazine-Piperidine is ideal for research applications involving targeted protein degradation and cellular signaling pathways.
Grouped product items
Size Price Stock Qty
5mg
$295.00
In stock
10mg
$500.00
In stock
25mg
$955.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionThalidomide-Piperazine-Piperidine is a synthesized E3 ligase ligand-linker conjugate that targets cereblon, a key component in the ubiquitin-proteasome system. This compound incorporates a Thalidomide-based ligand and a piperazine-piperidine linker, making it suitable for use in PROTAC (proteolysis-targeting chimeras) technology. Its design facilitates targeted degradation of specific proteins, providing valuable insight into protein regulation and function in various biological contexts. Thalidomide-Piperazine-Piperidine is ideal for research applications involving targeted protein degradation and cellular signaling pathways.
Product Information
Catalog NumA31564
FormulaC22H27N5O4
Molecular Weight425.48
CAS Number2229716-11-2
SMILESO=C1C(CCC(N1)=O)N2C(C3=C(C=CC(N4CCN(CC4)C5CCNCC5)=C3)C2=O)=O
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