Thiamiprine is a nucleoside antimetabolite and analog related to azathioprine, primarily targeting DNA synthesis. This compound exhibits cytotoxic effects in vitro, demonstrating activity comparable to its parent compound, though its arabinoside variant is inactive and non-toxic. In vivo studies using the rat adjuvant arthritis model indicate that the riboside and 2'-deoxyriboside forms are less active than the parent compound, while maintaining a distinct safety profile. Thiamiprine is valuable for research applications focused on immunosuppression and cellular proliferation.
Thiamiprine is a nucleoside antimetabolite and analog related to azathioprine, primarily targeting DNA synthesis. This compound exhibits cytotoxic effects in vitro, demonstrating activity comparable to its parent compound, though its arabinoside variant is inactive and non-toxic. In vivo studies using the rat adjuvant arthritis model indicate that the riboside and 2'-deoxyriboside forms are less active than the parent compound, while maintaining a distinct safety profile. Thiamiprine is valuable for research applications focused on immunosuppression and cellular proliferation.
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