Fig. 1 · Structure
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Thiamiprine
Nucleoside Antimetabolite/Analog
Thiamiprine is a nucleoside antimetabolite and analog related to azathioprine, primarily targeting DNA synthesis. This compound exhibits cytotoxic effects in vitro, demonstrating activity comparable to its parent compound, though its arabinoside variant is inactive and non-toxic. In vivo studies using the rat adjuvant arthritis model indicate that the riboside and 2'-deoxyriboside forms are less active than the parent compound, while maintaining a distinct safety profile. Thiamiprine is valuable for research applications focused on immunosuppression and cellular proliferation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 5581-52-2 |
| Applications | Nucleoside Antimetabolite/Analog |
| Formula | C9H8N8O2S |
| Molecular Weight | 292.28 |
| Synonyms | BW 57-323 |
| SMILES | NC1=NC(SC2=C([N+]([O-])=O)N=CN2C)=C3NC=NC3=N1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.