Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a modified phospholipid that serves as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). With an IC50 value of 2 μM at a substrate concentration of 0.5 mM, Thioetheramide-PC interacts with both the catalytic and activation sites of the enzyme, exhibiting tighter binding to the activation site. This unique dual interaction may facilitate phospholipase activation at low concentrations, making Thioetheramide-PC a valuable tool for studying sPLA2-related biological processes and mechanisms.
Thioetheramide-PC (1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine) is a modified phospholipid that serves as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2). With an IC50 value of 2 μM at a substrate concentration of 0.5 mM, Thioetheramide-PC interacts with both the catalytic and activation sites of the enzyme, exhibiting tighter binding to the activation site. This unique dual interaction may facilitate phospholipase activation at low concentrations, making Thioetheramide-PC a valuable tool for studying sPLA2-related biological processes and mechanisms.
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