Ticlopidine-d4 is a stable isotope-labeled form of Ticlopidine, an antithrombotic agent that functions as an allosteric, noncompetitive inhibitor of the enzyme CD39, exhibiting an IC50 of 81.7 μM. Additionally, Ticlopidine-d4 inhibits multiple NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3. It also serves as an inhibitor of cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP3A4, with respective IC50 values of 26.0 μM and 32.3 μM. This reagent is valuable for studying the pharmacodynamics and metabolism of Ticlopidine in biochemical research.
Ticlopidine-d4 is a stable isotope-labeled form of Ticlopidine, an antithrombotic agent that functions as an allosteric, noncompetitive inhibitor of the enzyme CD39, exhibiting an IC50 of 81.7 μM. Additionally, Ticlopidine-d4 inhibits multiple NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3. It also serves as an inhibitor of cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP3A4, with respective IC50 values of 26.0 μM and 32.3 μM. This reagent is valuable for studying the pharmacodynamics and metabolism of Ticlopidine in biochemical research.
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