Tigecycline

Catalog No.: A10933

Tigecycline

Tigecycline Chemical Structure

CAS NO. 220620-09-7

Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.

Availability: In stock

Package Price Qty
10 mg
$55.00
25 mg
$80.00
50 mg
$110.00
100 mg
$190.00
10mM * 1mL in DMSO
$55.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sato T, .et al. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages, Microb Drug Resist, 2018, Jul/Aug;24(6):860-867 PMID: 29232167
  • Dinah B. Aziz, .et al. Teicoplanin - Tigecycline Combination Shows Synergy Against Mycobacterium abscessus, Front Microbiol, 2018, May 11 PMID: 29867841
  • Toyotaka Sato, .et al. Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648, Antimicrob Agents Chemother, 2017, Feb; 61(2): e01654-16 PMID: 27855067

Biological Activity

Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.
In vitro (25°C) DMSO 86 mg/mL (146.85 mM)
Water 86 mg/mL (146.85 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.07 mL 85.37 mL 170.74 mL
0.5 mM 3.41 mL 17.07 mL 34.15 mL
1 mM 1.71 mL 8.54 mL 17.07 mL
5 mM 0.34 mL 1.71 mL 3.41 mL

*The above data is based on the productmolecular weight 585.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10933
CAS No. 220620-09-7
Formula C29H39N5O8
M. Wt 585.7
Purity >98%
Synonyms Tygacil, GAR-936, WAY-GAR-936, TBG-MINO
SMILES CC(C)(C)NCC(=O)NC1=C(C2=C(C[[email protected]]3C[[email protected]]4[[email protected]@H](C(=O)C(=C([[email protected]]4(C(=O)C3=C2O)O)O)C(=O)N)N(C)C)C(=C1)N(C)C)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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