Tiplaxtinin (PAI-039)

Catalog No.: A14190

PAI-1 inhbitor

Tiplaxtinin (PAI-039)

Tiplaxtinin (PAI-039) Chemical Structure

CAS NO. 393105-53-8

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.

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5 mg
$75.00
10 mg
$85.00
25 mg
$200.00
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  • Saijo A, .et al. Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells, Cancer Lett, 2018, May 1;421:17-27 PMID: 29448000

Biological Activity

Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 μM.
Targets
PAI-1
2.7 μM
In vitro (25°C) DMSO 62 mg/mL (141.1 mM)
Water Insoluble
Ethanol Warmed: 15 mg/mL (34.13 mM)
In vivo 2.0% Tween 80+0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.76 mL 113.8 mL 227.59 mL
0.5 mM 4.55 mL 22.76 mL 45.52 mL
1 mM 2.28 mL 11.38 mL 22.76 mL
5 mM 0.46 mL 2.28 mL 4.55 mL

*The above data is based on the productmolecular weight 439.3833. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14190
Actions Inhibitor
CAS No. 393105-53-8
Formula C24H16F3NO4
M. Wt 439.3833
Solubility DMSO
Purity >98%
Synonyms PAI-039
SMILES C1=CC=C(C=C1)CN2C=C(C3=C2C=CC(=C3)C4=CC=C(C=C4)OC(F)(F)F)C(=O)C(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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