Tizanidine-d4 is a deuterated form of Tizanidine, a central α2-adrenoceptor agonist known for its muscle relaxant properties. It primarily acts by inhibiting the release of excitatory amino acids such as glutamate and aspartate in the spinal cord, contributing to skeletal muscle relaxation. Research has demonstrated its ability to inhibit the proliferation, migration, and invasion of lung cancer cells, as well as induce apoptosis through modulation of the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine is clinically applied for managing spasticity associated with conditions like multiple sclerosis, stroke, and spinal cord injury.
Tizanidine-d4 is a deuterated form of Tizanidine, a central α2-adrenoceptor agonist known for its muscle relaxant properties. It primarily acts by inhibiting the release of excitatory amino acids such as glutamate and aspartate in the spinal cord, contributing to skeletal muscle relaxation. Research has demonstrated its ability to inhibit the proliferation, migration, and invasion of lung cancer cells, as well as induce apoptosis through modulation of the AKT and Wnt3a/β-catenin signaling pathways. Tizanidine is clinically applied for managing spasticity associated with conditions like multiple sclerosis, stroke, and spinal cord injury.
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