Topoisomerase I/II inhibitor 3

Catalog No.: A32906
Topoisomerase I/III Inhibitor
Topoisomerase I/II inhibitor 3 is a dual inhibitor targeting both topoisomerase I and II. This compound exhibits potent anti-proliferative effects, inhibiting cell proliferation, invasion, and migration, while also inducing apoptosis through the PI3K/Akt/mTOR signaling pathway. It is particularly relevant for research applications in liver cancer studies.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTopoisomerase I/II inhibitor 3 is a dual inhibitor targeting both topoisomerase I and II. This compound exhibits potent anti-proliferative effects, inhibiting cell proliferation, invasion, and migration, while also inducing apoptosis through the PI3K/Akt/mTOR signaling pathway. It is particularly relevant for research applications in liver cancer studies.
Product Information
Catalog NumA32906
FormulaC24H24N2O4
Molecular Weight404.46
CAS Number2770804-74-3
SMILESC1(C=CC2=C3C=NC(C4=CC5=C(OCO5)C=C4CN6CCCCCC6)=C2)=C3OCO1
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