Topotecan

Catalog No.: A16815

Topoisomerase inhibitor

Topotecan

Topotecan Chemical Structure

CAS NO. 123948-87-8

Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.

Availability: In stock

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10 mg

Regular Price: $50.00

Special Price $40.00

50 mg

Regular Price: $180.00

Special Price $144.00

100 mg

Regular Price: $300.00

Special Price $240.00

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Biological Activity

Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.
In vitro DMSO 76 mg/mL (180.33 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.73 mL 118.64 mL 237.28 mL
0.5 mM 4.75 mL 23.73 mL 47.46 mL
1 mM 2.37 mL 11.86 mL 23.73 mL
5 mM 0.47 mL 2.37 mL 4.75 mL

*The above data is based on the productmolecular weight 421.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16815
Actions Inhibitor
CAS No. 123948-87-8
Formula C23H23N3O5
M. Wt 421.45
Purity >98%
Synonyms SKF104864, SKF 104864, SKF-104864, NSC 609669, NSC609669, NSC-609669
SMILES O=C1[[email protected]](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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