TP003 is a non-selective agonist at the benzodiazepine site of the GABAA receptor, exhibiting EC50 values of 20.3 nM for α1β2γ2, 10.6 nM for α2β3γ2, 3.24 nM for α3β3γ2, and 5.64 nM for α5β2γ2. This compound demonstrates significant anxiolytic activity primarily through interaction with the α2 GABAA receptor subtype. TP003 is valuable for research into anxiety disorders and other neuropharmacological applications, providing insights into GABAA receptor-mediated anxiolysis.
TP003 is a non-selective agonist at the benzodiazepine site of the GABAA receptor, exhibiting EC50 values of 20.3 nM for α1β2γ2, 10.6 nM for α2β3γ2, 3.24 nM for α3β3γ2, and 5.64 nM for α5β2γ2. This compound demonstrates significant anxiolytic activity primarily through interaction with the α2 GABAA receptor subtype. TP003 is valuable for research into anxiety disorders and other neuropharmacological applications, providing insights into GABAA receptor-mediated anxiolysis.
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