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Catalog No.
Product Name
Application
Product Information
Citations
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Serotonin Reuptake Inhibitor
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter, resulting in increased serotonergic neurotransmission. This compound is utilized for its antidepressant properties and is effective in the treatment of major depressive disorder and anxiety-related conditions. Research applications include studies on mood regulation and neurotransmitter dynamics. -
Serotonin Transporter Inhibitor
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter. It is primarily used in the treatment of obsessive-compulsive disorder and depression by increasing serotonin levels in the synaptic cleft. This compound is valuable in research applications exploring mood regulation, anxiety disorders, and the neural mechanisms underlying depression. -
SERT Inhibitor
SERT-IN-2 is a potent serotonin transporter (SERT) inhibitor, demonstrating an IC50 of 0.58 nM. This compound exhibits significant anti-depressive activity and shows a high bioavailability of 83.28% in rat models. Additionally, SERT-IN-2 possesses the ability to cross the blood-brain barrier, making it a valuable tool for research into mood disorders and related pharmacological studies. -
Serotonin Reuptake Inhibitor
(S)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily utilized in the treatment of major depressive disorder and anxiety disorders. By increasing serotonin levels in the brain, it enhances mood and alleviates symptoms of depression. This compound is frequently employed in pharmacological studies related to depression, anxiety, and other mood disorders, making it valuable for researchers exploring therapeutic interventions in neuropsychology. -
NET/SERT Inhibitor
Desmethyl Sibutramine hydrochloride is a potent norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. As a secondary metabolite of Sibutramine, it plays a significant role in modulating neurotransmitter levels associated with appetite regulation. This compound is utilized in research focused on obesity and the development of appetite suppressant therapies. -
NET/SERT Inhibitor
Ampreloxetine hydrochloride is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT), with no activity against the dopamine transporter (DAT). It shows binding affinities with EC50 values of 11.7 ng/mL for NET and 50.8 ng/mL for SERT in plasma. This compound is utilized in research related to mood disorders and anxiety, offering insights into the modulation of norepinephrine and serotonin levels within the central nervous system. -
Serotonin Reuptake Inhibitor
(R)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily targeting the serotonin transporter. This compound demonstrates a modest affinity for the 5-HT2A and 5-HT2C receptors, contributing to its pharmacological profile. It is widely utilized in research related to depression, anxiety disorders, and other serotonin-related dysfunctions. -
Serotonin Transporter Inhibitor
Dapoxetine-d7 hydrochloride is a deuterium-labeled derivative of Dapoxetine hydrochloride, specifically targeting the serotonin transporter. This compound acts as a selective serotonin reuptake inhibitor (SSRI) with a short duration of action. Dapoxetine-d7 hydrochloride is employed in pharmacokinetic studies, providing insights into the metabolism and distribution of SSRIs in biological systems. -
NET/SERT Inhibitor
Desmethyl Sibutramine is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT). This compound demonstrates significant biological activity in modulating neurotransmitter levels, making it a valuable tool in obesity research and the study of appetite suppression mechanisms. Its metabolic profile and pharmacological effects contribute to its utility in understanding weight management therapies. -
Serotonin Transporter Inhibitor
Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation. -
Serotonin-norepinephrine Reuptake Inhibitor
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that plays a critical role in investigating the pathophysiology of depression and related mood disorders. By modulating the levels of serotonin and norepinephrine in the synaptic cleft, Ansofaxine enhancing neurotransmitter availability and activity. This compound is valuable for research applications focused on the mechanisms of action of SNRIs in the treatment of depression and for exploring new therapeutic strategies. -
SSRI Inhibitor
Paroxetine maleate is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter (SERT). It exhibits significant efficacy in modulating serotonergic activity, making it valuable in the study of mood and anxiety disorders. Paroxetine maleate is commonly utilized in research related to generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and chronic headache conditions. -
Serotonin Transporter Inhibitor
(R)-Duloxetine hydrochloride is a selective serotonin transporter inhibitor primarily used in pharmacological studies. It demonstrates significant binding affinity and is of interest in investigations related to serotonin reuptake mechanisms. Unlike its enantiomer (S)-Duloxetine, (R)-Duloxetine has limited effectiveness as a dual reuptake inhibitor for serotonin and norepinephrine, making it a valuable compound for research on monoaminergic neurotransmission and related disorders. -
NE Reuptake Inhibitor
Tampramine fumarate is a potent and selective noncompetitive inhibitor of norepinephrine (NE) reuptake. This compound exhibits significant antidepressant activity, making it a valuable tool for studying depression and its related mechanisms. Researchers can utilize Tampramine fumarate to investigate the role of NE reuptake inhibition in neuropharmacology and the development of antidepressant therapies. -
Serotonin Transporter Inhibitor
Nitroxazepine hydrochloride is a potent serotonin transporter inhibitor functioning as a tricyclic antidepressant (TCA). It enhances serotonergic and noradrenergic neurotransmission by inhibiting the reuptake of serotonin and norepinephrine, making it a valuable compound for research into the mechanisms of depression and related mood disorders. Its role in modulating serotonin levels also provides insights into the pharmacological treatment options for various psychiatric conditions. -
Serotonin Re-uptake Inhibitor
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine, acting as a potent serotonin reuptake inhibitor, with a Ki of 13 nM. This compound is primarily utilized in research focusing on the pathophysiology and treatment of depression. Its selective inhibition of serotonin reuptake makes it an essential tool for studying serotonergic signaling and therapeutic interventions in mood disorders. -
Serotonin Reuptake Inhibitor
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is orally active. It has been primarily investigated for its biological activity in the treatment of premature ejaculation (PE). Dapoxetine's mechanism of action enhances serotonergic signaling, contributing to increased ejaculatory control and prolonged intravaginal ejaculatory latency. This makes Dapoxetine a valuable reagent in sexual health research and studies focused on sexual dysfunction. -
Norepinephrine Reuptake Inhibitor
Tametraline is a norepinephrine reuptake inhibitor that modulates the levels of norepinephrine in the synaptic cleft. This compound exhibits significant antidepressant activity and is primarily utilized in research investigating neurological disorders, particularly depression. Its mechanism of action may provide insights into the treatment and understanding of mood-related pathologies. -
SerT Inhibitor
SERT-IN-3 is a potent inhibitor of the serotonin transporter (SerT), displaying an IC50 value of 34.4 nM in pharmacological assays. This compound plays a critical role in research applications focused on serotonin modulation, making it a valuable tool for studying neuropharmacology and potential therapeutic interventions in mood and anxiety disorders. -
Serotonin Transporter Inhibitor
(±)-Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor targeting the serotonin transporter. This compound exhibits significant analgesic and antidepressant properties, making it valuable in studies related to diabetic neuropathic pain, fibromyalgia, and major depressive disorder. Researchers utilize (±)-Duloxetine hydrochloride to explore its potential therapeutic effects and underlying mechanisms in various neuropathic and mood disorders. -
Serotonin Transporter Inhibitor
(S)-Venlafaxine is a potent serotonin transporter inhibitor that also affects norepinephrine reuptake. This compound is recognized for its antidepressant properties and is utilized in research to investigate mechanisms of mood disorders and neuropharmacology. Its dual inhibitory action on 5-HT and NE transporters makes it a valuable tool for studying depression and anxiety-related pathways. -
Dual Serotonin and Noradrenaline Monoamine reuptake Inhibitor
SNRI-IN-1 is a dual serotonin and noradrenaline monoamine reuptake inhibitor that demonstrates significant activity in modulating neurotransmitter levels. With a P-glycoprotein Efflux Ratio of 20, this compound is useful in studying the dynamics of monoamine transport and its implications in mood disorders and cognitive function. Research applications include investigating the effects of dual inhibition on neurotransmission and potential therapeutic benefits in conditions such as depression and anxiety. -
Serotonin-norepinephrine Reuptake Inhibitor
Duloxetine-d3 hydrochloride is a deuterium-labeled derivative of Duloxetine hydrochloride, functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. This compound is primarily utilized in research to study the pharmacokinetics and biological effects of Duloxetine in models of major depressive disorder and generalized anxiety disorder. Its stable isotope labeling enables precise tracking in metabolic studies and enhances the understanding of drug metabolism and action mechanisms. -
5-hydroxytryptamine Uptake Inhibitor
Serotonin azidobenzamidine is a selective inhibitor of 5-hydroxytryptamine (serotonin) uptake, functioning through competitive inhibition. It demonstrates significant biological activity with a Ki value of 130 nM, effectively inhibiting [3H]5-hydroxytryptamine uptake in rat cortical synaptosomes. This reagent is valuable in neuropharmacological research, aiding in the study of serotonin modulation and its effects on various physiological processes. -
Serotonin Transporter Inhibitor
(S)-Tomoxetine hydrochloride is a selective serotonin transporter inhibitor known for its ability to modulate serotonin levels in synaptic clefts. With a reported inhibition constant (Ki) of 16.8 nM, it effectively inhibits the reuptake of norepinephrine, thereby influencing neurotransmitter dynamics. This compound is utilized in research focused on neuropharmacology, mood disorders, and the mechanisms of serotonin signaling. -
Serotonin Reuptake Inhibitor
(S)-Norfluoxetine is a selective serotonin reuptake inhibitor that primarily targets the serotonin transporter. It has been shown to enhance allopregnanolone levels and decrease aggressive behavior in socially isolated murine models. This compound is valuable in research related to neuropharmacology and the understanding of mood and anxiety disorders. -
SERT Inhibitor
Nardosinonediol is a selective serotonin transporter (SERT) inhibitor. It demonstrates significant modulation of serotonin uptake, making it a valuable tool for studying serotonin-related pathways. This compound is primarily used in research focused on neuropharmacology, mood disorders, and the development of antidepressant therapies. -
Serotonin Reuptake Inhibitor
(Rac)-Dapoxetine hydrochloride is a racemic mixture of Dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) that primarily targets serotonin transporters. This compound exhibits notable efficacy in the treatment of premature ejaculation (PE) and is valuable in research aimed at understanding this condition. Its pharmacological profile positions it as a significant tool for studying serotonin-related pathways in human sexual health. -
Serotonin Reuptake Inhibitor
DA-8031 is a selective serotonin reuptake inhibitor (SSRI) with oral bioavailability. It demonstrates the ability to modulate serotonin levels, making it a valuable compound for studying conditions related to serotonin dysregulation, particularly premature ejaculation (PE). This compound serves as an important tool for research into therapeutic interventions for PE and related disorders. -
Serotonin Reuptake Inhibitor
Lubazodone is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter. It exhibits significant antidepressant activity and is utilized in the investigation of various depressive disorders. Research applications include exploring its effects on mood regulation and neurochemical pathways associated with depression. -
H+, K+-ATPase Inhibitor
Esomeprazole magnesium, a potent H+, K+-ATPase inhibitor, is utilized in research related to upper intestinal disorders and gastroesophageal reflux disease. Its primary mechanism involves the inhibition of proton pumps, leading to decreased gastric acid secretion. Additionally, Esomeprazole magnesium exhibits properties as an exosome inhibitor by blocking exosome release through the inhibition of vacuolar H+-ATPases, making it valuable for studies on cellular communication and disease progression. -
Sodium Channel Inhibitor
Mepivacaine hydrochloride is a sodium channel inhibitor that selectively binds to voltage-gated sodium ion channels in neuronal cell membranes. By inhibiting sodium influx and membrane depolarization, it provides significant local anesthetic effects. This compound is widely used in research applications related to nerve conduction studies and pain management investigations. -
SERCA Inhibitor
2,5-Di-tert-butylhydroquinone is a potent inhibitor of Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), demonstrating an IC50 of 400 nM. This compound disrupts the gating function of Glu309, thereby preventing calcium ions from accessing their binding site. Additionally, 2,5-Di-tert-butylhydroquinone influences the activity of key enzymes such as 5-lipoxygenase and COX-2, with IC50 values of 1.8 μM and 14.1 μM, respectively. It is utilized in research focused on cellular calcium regulation and inflammatory processes. -
Bacterial Inhibitor
Methyl Paraben is a bacterial inhibitor primarily used as a preservative in various applications due to its stability and non-volatility. It has been shown to enhance histamine release and modulate cellular immune responses, in addition to blocking sodium channels. Its properties make it valuable for studies exploring microbial inhibition and the mechanisms of ischemia-reperfusion injury. -
TASK-1 Inhibitor
Doxapram hydrochloride hydrate is a TASK-1 inhibitor that enhances respiratory function by stimulating the brain's respiratory centers and peripheral chemoreceptors. This compound effectively increases both the rate and depth of breathing, while demonstrating inhibitory effects on TASK-1, TASK-3, and their heterodimeric channels with EC50 values of 410 nM, 37 μM, and 9 μM, respectively. Additionally, it inhibits Ca²⁺-activated and Ca²⁺-independent potassium currents in type I cells of the carotid body, with IC50 values of approximately 13 μM and 20 μM, respectively. Doxapram hydrochloride hydrate serves as a useful reagent for research on respiratory depression conditions, including post-anesthesia recovery, chronic obstructive pulmonary disease, and apnea of prematurity. -
Calcium Channel Inhibitor
Ethosuximide is a calcium channel inhibitor primarily targeting T-type calcium channels, specifically blocking low voltage-activated currents. This compound is extensively used in research for its anti-epileptic properties as well as its potential therapeutic effects in various neurodegenerative disease models. Ethosuximide facilitates the study of calcium signaling pathways and their involvement in neuronal excitability and degeneration. -
Dopamine Receptor Inhibitor
Fluphenazine dihydrochloride is a potent dopamine receptor antagonist primarily targeting dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative also exhibits the ability to inhibit neuronal voltage-gated sodium channels. Its key biological activities include the suppression of Methylphenidate-induced stereotyped behaviors and climbing in murine models. Fluphenazine dihydrochloride is widely utilized in research related to psychosis, diabetic peripheral neuropathy, and may also have implications for the inhibition of SARS-CoV-2. -
Sodium Channel Inhibitor
Oxybuprocaine hydrochloride is a sodium channel inhibitor that reversibly blocks sodium channels, effectively preventing the propagation of painful nerve impulses in tissues such as the cornea, conjunctiva, and sclera. This compound is primarily utilized in ophthalmology and otolaryngology for its anesthetic properties, providing localized pain relief during various medical procedures. Its ability to inhibit nerve signal transmission makes it valuable for both diagnostic and therapeutic applications in ocular and ear, nose, and throat treatments. -
Sodium Channel Inhibitor
Propafenone hydrochloride is a sodium channel inhibitor primarily used as an anti-arrhythmic agent. It effectively treats conditions related to rapid heartbeats, including atrial and ventricular arrhythmias. This compound is useful in research applications focused on cardiac rhythm disturbances and the pharmacological modulation of ion channels. -
Sodium Channel Inhibitor
Triamterene is a sodium channel inhibitor that selectively blocks epithelial Na+ channels (ENaC) in a voltage-dependent manner. It exhibits mild diuretic properties and is utilized in the management of conditions related to fluid retention. Additionally, Triamterene serves as an inhibitor of the TGR5 receptor, contributing to its diverse biological effects and applications in research related to renal and metabolic processes. -
Sodium Channel Inhibitor
Ropivacaine mesylate acts primarily as a sodium channel inhibitor, serving as a long-acting amide local anesthetic. It effectively blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers, making it suitable for procedures requiring spinal block anesthesia. Additionally, Ropivacaine has been identified as an inhibitor of the K2P potassium channel TREK-1, exhibiting an IC50 value of 402.7 μM in COS-7 cell membranes. This compound is relevant for research into pain management and neuronal activity modulation. -
Sodium Channel Inhibitor
Mepivacaine is an amide-type local anesthetic that functions as a sodium channel inhibitor. By binding to specific voltage-gated sodium ion channels in neuronal cell membranes, Mepivacaine effectively inhibits sodium influx and membrane depolarization. This agent is primarily utilized in various research applications within the fields of pain management and anesthesia. -
Potassium Channel Inhibitor
Cloperastine hydrochloride is a potassium channel inhibitor primarily targeting hERG K+ currents. It demonstrates concentration-dependent inhibition, with an IC50 value of 27 nM. This reagent is employed in research applications focused on cardiac ion channel function and drug interactions, providing valuable insights into cardiovascular safety and pharmacology. -
Proton Pump Inhibitor
Ilaprazole sodium is a potent proton pump inhibitor that irreversibly targets H+/K+-ATPase, demonstrating a dose-dependent inhibition with an IC50 of 6 μM in rabbit parietal cell assays. This compound is primarily utilized in research focused on gastric ulcers, providing insights into gastric acid secretion regulation. Additionally, Ilaprazole sodium acts as an effective inhibitor of TOPK (T-lymphokine-activated killer cell-originated protein kinase), facilitating studies related to immune responses and cancer therapeutics. -
VMAT2 Inhibitor
Valbenazine tosylate is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2), exhibiting a Ki value in the range of 110-190 nM. It is primarily employed in research related to neuropharmacology and the treatment of movement disorders, such as tardive dyskinesia. By inhibiting VMAT2, Valbenazine tosylate modulates neurotransmitter release, making it a valuable tool for studying dopaminergic signaling and associated pathologies. -
Sodium Channel Inhibitor
Riluzole hydrochloride is a sodium channel inhibitor that exhibits anticonvulsant properties. It functions primarily as a use-dependent Na+ channel blocker and also has the capability to inhibit GABA uptake, with an IC50 of 43 μM. This compound is commonly utilized in neurological research applications, particularly in studies focused on epilepsy and neuroprotection. -
Sodium Channel Inhibitor
Ropivacaine hydrochloride is a potent sodium channel inhibitor that effectively disrupts impulse conduction by reversibly blocking sodium ion influx in nerve fibers. Additionally, it inhibits the K2P TREK-1 potassium channel with an IC50 of 402.7 μM in COS-7 cell membranes. This compound is primarily applied in the management of neuropathic pain in various in vivo research contexts. -
Potassium Channel Inhibitor
Cloperastine fendizoate is a potent inhibitor of the hERG potassium channels, exhibiting concentration-dependent inhibition with an IC50 value of 27 nM. This compound is primarily utilized in research applications focusing on cardiac ion channel function and related arrhythmia studies. Its effects on potassium currents make it valuable for investigating the electrophysiological properties of cardiac tissues and potential therapeutic interventions. -
Sodium Channel Inhibitor
Propoxycaine hydrochloride is a sodium channel inhibitor that disrupts voltage-gated sodium channel activity, leading to a reduction in ionic flux essential for the initiation and propagation of action potentials. This compound is primarily utilized in research to investigate sensory nerve function and analgesic mechanisms, resulting in local anesthetic effects characterized by a loss of sensation. -
Potassium Channel Inhibitor
Tetraethylammonium chloride is a non-selective inhibitor of potassium channels, effectively blocking their function. This compound is recognized as a substrate for organic cation transporter 1 (OCTN1), which may be relevant in transport-related studies. Additionally, tetraethylammonium chloride exhibits potential antitumor properties, making it a valuable tool in cancer research and investigations into ion channel dynamics.
