Trap-101 hydrochloride is a potent and selective antagonist of the nociceptin/orphanin FQ peptide (NOP) receptor. It demonstrates a strong competitive binding affinity, as evidenced by GTPγ35S binding assays in CHOhNOP membranes, with pKi values of 8.65 for NOP and significantly lower values for classical opioid receptors. Trap-101 has been shown to alleviate motor deficits in rat models of Parkinson's disease, positioning it as a valuable tool for studying nervous system disorders and their underlying mechanisms.
Trap-101 hydrochloride is a potent and selective antagonist of the nociceptin/orphanin FQ peptide (NOP) receptor. It demonstrates a strong competitive binding affinity, as evidenced by GTPγ35S binding assays in CHOhNOP membranes, with pKi values of 8.65 for NOP and significantly lower values for classical opioid receptors. Trap-101 has been shown to alleviate motor deficits in rat models of Parkinson's disease, positioning it as a valuable tool for studying nervous system disorders and their underlying mechanisms.
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