Trimipramine maleate is a selective 5-HT receptor antagonist that effectively crosses the blood-brain barrier. It demonstrates significant binding affinity with pKi values of 6.39, 8.10, and 4.66 for the 5-HT1C, 5-HT2, and 5-HT1A receptors, respectively. Additionally, Trimipramine maleate acts as an inhibitor of human noradrenaline transporter (hNAT), serotonin transporter (hSERT), and organic cation transporters (hOCT1, hOCT2), with IC50 values of 4.99 μM, 2.11 μM, and 3.72 μM, and 8.00 μM, respectively. Its unique pharmacological profile also indicates potential applications in vascular activity and anxiety treatment research.
Trimipramine maleate is a selective 5-HT receptor antagonist that effectively crosses the blood-brain barrier. It demonstrates significant binding affinity with pKi values of 6.39, 8.10, and 4.66 for the 5-HT1C, 5-HT2, and 5-HT1A receptors, respectively. Additionally, Trimipramine maleate acts as an inhibitor of human noradrenaline transporter (hNAT), serotonin transporter (hSERT), and organic cation transporters (hOCT1, hOCT2), with IC50 values of 4.99 μM, 2.11 μM, and 3.72 μM, and 8.00 μM, respectively. Its unique pharmacological profile also indicates potential applications in vascular activity and anxiety treatment research.
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