Inhibition of metformin uptake in HEK-OCT2 cells
Cell-based study · HEK-OCT2 cells; n = 6 [1]
In HEK-OCT2 cells, Trospium chloride inhibited OCT2-dependent uptake of metformin with an IC50 of 0.07 μM.
| Endpoint | Reported result | Reference |
|---|---|---|
| IC50 values for inhibition of OCT2-dependent uptake of metformin | IC50 0.07 μM | [1] |
Literature-Reported Treatment Conditions
- Exposure duration
- 37°C for 3 min
- Method
- in the presence of increasing concentrations of test drugs
- Reported limits
- Not stated in the sentences used: dose, vehicle.
Methods and source locations
Compound reported in the paper: Trospium chloride
Literature evidence for the named compound in the stated model; no Adooq product-use or lot-performance claim.
Materials and Methods > Transport Assays in HEK-OCT2 Cells (S15, S17, S18); Materials and Methods > IC50 Determination (S31, S32, S35); Fig 5 legend (S112); Table 1 legend (S114); Table 1 (T1.h1, T1.r8)
IC50 values for inhibition of OCT2-dependent uptake of metformin: IC50 values for inhibition of OCT2-dependent uptake of metformin; comparator: net uptake in the absence of the inhibitor — Table 1 legend (S114); Table 1 (T1.h1, T1.r8)