Catalog No.
Product Name
Application
Product Information
Product Citation
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muscarinic receptor antagonist
Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype -
Muscarinic receptor agonist
Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors. -
AChR antagonist
Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence -
mAChR M2 antagonist
Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. - Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.
- Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
- Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M).
- Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.
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AchR antagonist
Rocuronium Bromide is a competitive AchR antagonist, used in modern anaesthesia. -
muscarinic receptor antagonist
SVT-40776 is a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. -
muscarinic acetylcholine receptor (mAChR) antagonist
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. -
muscarinic receptor antagonist
Tolterodine tartrate (Detrol LA) is a muscarinic receptor antagonist which is used for the treatment of urinary incontinence. -
muscarinic receptor antagonist
5-hydroxymethyl tolterodine is a metabolite of Tolterodine, a muscarinic receptor antagonist used in the treatment of urinary incontinence.
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muscarinic M3 receptor antagoinst
Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence. -
Nicotinic receptor agonist
Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the ??4??2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM). -
NMDA receptor antagonist
Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker. - Methoctramine hydrate is a selective M2 muscarinic receptor antagonist at nM concentrations
- Lingyu Wang, .et al. , Gut Microbes, 2020, 12(1): 1-20 PMID: 33006494
- Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions.
- Catharanthine sulfate is a vinblastine-type alkaloid precursor with antitumor activity. It inhibits AChR by ion channel blocking and desensitization.
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muscarinic receptor inhibitor
Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1. -
muscarinic antagonist
Glycopyrrolate is a muscarinic competitive antagonist used as an antispasmodic. -
muscarinic M(3) receptor antagonist
PF-3635659 is a potent muscarinic M(3) receptor antagonist. -
mAChR agonist
Xanomeline oxalate is a potent agonist of muscarinic acetylcholine receptors (EC50 values are 0.3, 92.5, 5, 52, and 42 nM for M1, M2, M3, M4, and M5, respectively). - (-)-Nicotine ditartrate is a potent agonist of AChR (nicotinic acetylcholine recepto).
- Guochao Ni, .et al. , Reprod Biol Endocrinol, 2020, 18: 65 PMID: 32552695
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M2/M3 antagonist
Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02. -
M1 agonist
Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. -
Muscarinic receptor antagonist
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). -
M3 receptors inhibitor
Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). -
muscarinic receptor antagonist
Revefenacin is potent and selective muscarinic receptor antagonist in development for the treatment of COPD. - Acetylcholine iodide is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.
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Muscarinic receptor agonist
Methacholine chloride is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system. - Pirmenol hydrochloride inhibits IK.ACh by blocking muscarinic receptors. The IC50 of Pirmenol for inhibition of Carbachol-induced IK.ACh is 0.1 μM.
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mAChR antagonist
Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine. -
mAChR agonist
Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. -
alpha-1 adrenergic receptors / mAChRs inhibitor
Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. -
mAChR antagonist
Cimetropium Bromide (DA-3177) is a mAChR antagonist for long-term treatment of irritable bowel syndrome. -
partial M1 agonist and M2/M3 antagonist
Alvameline (Lu25-109) is a partial M1 agonist and M2/M3 antagonist. -
mAChR M5 positive allosteric modulator
VU 0365114 is a mAChR M5 positive allosteric modulator, with an EC50 of 2.7 μM.
