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mAChR

Muscarinic acetylcholine receptors (mAChRs) are a class of G protein-coupled receptors (GPCRs) found in the central and peripheral nervous systems, as well as in various other tissues and organs throughout the body. These receptors are named after muscarine, a natural alkaloid compound found in certain mushrooms, which was one of the first substances discovered to activate them.

There are five subtypes of muscarinic receptors, designated as M1 through M5, each with distinct tissue distribution and functions. Here's an overview of their roles:

  • M1 Receptors: Predominantly found in the central nervous system, particularly in regions associated with cognitive functions. Activation of M1 receptors is linked to memory and learning.
  • M2 Receptors: Found in the heart, where they play a crucial role in regulating heart rate and cardiac contractility. Activation of M2 receptors slows heart rate and reduces the force of cardiac contractions.
  • M3 Receptors: Present in smooth muscle tissues, such as those in the gastrointestinal tract, urinary bladder, and bronchial airways. Activation of M3 receptors leads to smooth muscle contraction.
  • M4 Receptors: Distributed mainly in the central nervous system and involved in modulating neurotransmitter release. Their role in cognition and neuropsychiatric disorders is of interest.
  • M5 Receptors: Located in certain areas of the brain and implicated in the modulation of dopamine release. Research suggests they may be relevant to Parkinson's disease and addiction.

Muscarinic receptors are activated by the neurotransmitter acetylcholine and play a vital role in regulating a wide range of physiological processes, including heart rate, smooth muscle contraction, glandular secretion, and neurotransmitter release. They are targets for various drugs, including anticholinergic agents, which block their activity, and drugs used to treat conditions like bradycardia and neurodegenerative disorders.

Understanding the functions and regulation of muscarinic acetylcholine receptors is essential for developing therapies that modulate their activity and for advancing our knowledge of how they contribute to various physiological and pathological processes in the body.

Items 1-25 of 399

  • LY2119620
    Cat. No.
    A14217
    CAS No.
    886047-22-9

    LY2119620

    Synonyms: LY-2219620

    LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

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    1 mg
    $45.00
    5 mg
    $95.00
    All 7 sizes
  • Atropine sulfate monohydrate
    Cat. No.
    A10098
    CAS No.
    5908-99-6

    Atropine sulfate monohydrate

    Synonyms: Atropisol; Atropt; Atropini sulfas; Tropine tropate

    Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5.

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    50 mg
    $20.00
    100 mg
    $25.00
    All 3 sizes
  • Biperiden HCl
    Cat. No.
    A10147
    CAS No.
    1235-82-1

    Biperiden HCl

    Synonyms: Akineton

    Biperiden hydrochloride is a muscarinic receptor antagonist that displays some selectivity for the M1 subtype

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    5 mg
    $90.00
    10 mg
    $150.00
    All 5 sizes
  • Bethanechol chloride
    Cat. No.
    A10180
    CAS No.
    590-63-6

    Bethanechol chloride

    Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.

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    200 mg
    $20.00
    500 mg
    $25.00
    All 5 sizes
  • Fesoterodine fumarate
    Cat. No.
    A10386
    CAS No.
    286930-03-8

    Fesoterodine fumarate

    Synonyms: Toviaz

    Fesoterodine fumarate is a medicine which is used in urinary urgency, reducing the frequency of passing urine and urge urinary incontinence

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    2 mg
    $30.00
    5 mg
    $45.00
    All 8 sizes
  • Ipratropium bromide
    Cat. No.
    A10476
    CAS No.
    22254-24-6

    Ipratropium bromide

    Synonyms: Atrovent; Apovent; Aerovent

    Ipratropium bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.

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    25 mg
    $20.00
    50 mg
    $35.00
    All 7 sizes
  • Irsogladine
    Cat. No.
    A10480
    CAS No.
    57381-26-7

    Irsogladine

    Rsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

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    100 mg
    $20.00
    500 mg
    $45.00
    All 4 sizes
  • Methscopolamine bromide
    Cat. No.
    A10579
    CAS No.
    155-41-9

    Methscopolamine bromide

    Methscopolamine bromide is a competitive antimuscarinic agent that blocks the binding of acetylcholine at muscarinic acetylcholine receptors (mAChR M).

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    25 mg
    $35.00
    50 mg
    $45.00
    All 6 sizes
  • Oxybutynin
    Cat. No.
    A10684
    CAS No.
    5633-20-5

    Oxybutynin

    Synonyms: Ditropan; Lyrinel XL; Oxytrol

    Oxybutynin(Ditropan) is an anticholinergic medication used to relieve urinary and bladder difficulties.

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    100 mg
    $40.00
    200 mg
    $55.00
    All 4 sizes
  • Tiotropium Bromide
    Cat. No.
    A10934
    CAS No.
    136310-93-5

    Tiotropium Bromide

    Synonyms: BA679 BR; BA 679

    Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

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    5 mg
    $30.00
    10 mg
    $30.00
    All 7 sizes
  • Trospium chloride
    Cat. No.
    A10951
    CAS No.
    10405-02-4

    Trospium chloride

    Trospium chloride is a selective and competitive antagonist of muscarinic acetylcholine receptors (mAChRs). It exhibits potent antimuscarinic activity by binding with high affinity to M1, M2, and M3 receptor subtypes, while showing no interaction with nicotinic cholinergic receptors. This compound is primarily utilized in research related to neurological conditions and to explore the pharmacological modulation of cholinergic signaling.

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    100 mg
    $25.00
    500 mg
    $45.00
    All 3 sizes
  • Quifenadine
    Cat. No.
    A11114
    CAS No.
    10447-39-9

    Quifenadine

    Quifenadine is a potent M3 receptor antagonist, exhibiting an IC50 value greater than 1000 nM. This compound is valuable for research into neurological diseases and related conditions. It serves as a tool for studying the role of M3 receptors in various biological systems and may contribute to the development of therapeutic strategies targeting these pathways.

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    10 mg
    $340.00
    100 mg
    $2,510.00
    All 2 sizes
  • Solifenacin succinate
    Cat. No.
    A11215
    CAS No.
    242478-38-2

    Solifenacin succinate

    Synonyms: YM905; Vesicare

    Solifenacin-succinate is a muscarinic M3 receptor antagoinst, used in treatment of urinary incontinence.

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    10 mg
    $20.00
    50 mg
    $25.00
    All 6 sizes
  • Cevimeline
    Cat. No.
    A11372
    CAS No.
    107233-08-9

    Cevimeline (AF-102B)

    Synonyms: AF102B

    Cevimeline (AF-102B) is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.

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    5 mg
    $580.00
    10 mg
    $980.00
    All 3 sizes
  • Darifenacin hydrobromide
    Cat. No.
    A11391
    CAS No.
    133099-07-7

    Darifenacin hydrobromide

    Synonyms: UK-88525 hydrobromide

    Darifenacin (UK-88525) hydrobromide is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin hydrobromide binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin hydrobromide can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin hydrobromide inhibits tumor growth in colorectal cancer cells and has anti-tumor effects.

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    5 mg
    $20.00
    10 mg
    $25.00
    All 6 sizes
  • Metanicotine
    Cat. No.
    A11545
    CAS No.
    15585-43-0

    Metanicotine

    Synonyms: Rivanicline; RJR 2403

    Metanicotine is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than ??7 receptors(Ki= 36000 nM).

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    5 mg
    $400.00
    10 mg
    $620.00
    All 5 sizes
  • Orphenadrine citrate
    Cat. No.
    A11712
    CAS No.
    4682-36-4

    Orphenadrine citrate

    Synonyms: Norflex

    Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

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    50 mg
    $20.00
    100 mg
    $25.00
    All 5 sizes

Items 1-25 of 399

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