Tubulin inhibitor 35 is a dual inhibitor targeting tubulin polymerization and topoisomerase I, with an IC50 of approximately 5.69 μM and 50 μM, respectively. This compound demonstrates significant anti-tumor activity, effectively inhibiting the migration and invasion of MGC-803 and RKO cell lines, and inducing apoptosis by arresting the cell cycle at the G2/M phase. With potent efficacy against gastrointestinal tumors, Tubulin inhibitor 35 exhibits an IC50 of 0.09 μM in MGC-803 and 0.2 μM in RKO cell lines, making it a valuable reagent for cancer research applications.
Tubulin inhibitor 35 is a dual inhibitor targeting tubulin polymerization and topoisomerase I, with an IC50 of approximately 5.69 μM and 50 μM, respectively. This compound demonstrates significant anti-tumor activity, effectively inhibiting the migration and invasion of MGC-803 and RKO cell lines, and inducing apoptosis by arresting the cell cycle at the G2/M phase. With potent efficacy against gastrointestinal tumors, Tubulin inhibitor 35 exhibits an IC50 of 0.09 μM in MGC-803 and 0.2 μM in RKO cell lines, making it a valuable reagent for cancer research applications.
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