Tubulin inhibitor 42 (Compound 14b) primarily targets β-microtubulin, exhibiting dose-dependent inhibition with an IC50 of 3.5 µM. This compound disrupts microtubule dynamics, leading to cancer cell cycle arrest in the G2/M phase and triggering apoptosis. Additionally, Tubulin inhibitor 42 demonstrates significant inhibitory effects on angiogenesis, both in vitro and in vivo, ultimately suppressing vascularization and tumor progression.
Tubulin inhibitor 42 (Compound 14b) primarily targets β-microtubulin, exhibiting dose-dependent inhibition with an IC50 of 3.5 µM. This compound disrupts microtubule dynamics, leading to cancer cell cycle arrest in the G2/M phase and triggering apoptosis. Additionally, Tubulin inhibitor 42 demonstrates significant inhibitory effects on angiogenesis, both in vitro and in vivo, ultimately suppressing vascularization and tumor progression.
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