Umibecestat (CNP520)

Catalog No.: A18987

BACE-1 inhibitor

Umibecestat (CNP520)

Umibecestat (CNP520) Chemical Structure

CAS NO. 1387560-01-1

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.

Availability: In stock

Package Price Qty
5 mg
$350.00
10 mg
$650.00
50 mg
$2,000.00
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Biological Activity

Umibecestat (CNP520) is a beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1) inhibitor with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.46 mL 97.31 mL 194.63 mL
0.5 mM 3.89 mL 19.46 mL 38.93 mL
1 mM 1.95 mL 9.73 mL 19.46 mL
5 mM 0.39 mL 1.95 mL 3.89 mL

*The above data is based on the productmolecular weight 513.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18987
Actions Inhibitor
CAS No. 1387560-01-1
Formula C19H15ClF7N5O2
M. Wt 513.8
Purity >98%
Synonyms CNP 520, CNP-520
SMILES O=C(NC1=NC([[email protected]@]2(CO[[email protected]](C)(C(N)=N2)C(F)(F)F)C)=C(C=C1)F)C3=NC=C(C=C3Cl)C(F)(F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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