Upidosin is an α-1 adrenergic receptor (α-1 AR) antagonist with moderate selectivity for the α-1A AR subtype. It demonstrates uroselectivity, exhibiting a Kb value of 2-3 nM in the urethra and prostate, compared to Kb values of 20-100 nM in the ear artery and aorta. Upidosin effectively inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptors. This compound is a valuable tool for research focused on urethral obstruction and related conditions.
Upidosin is an α-1 adrenergic receptor (α-1 AR) antagonist with moderate selectivity for the α-1A AR subtype. It demonstrates uroselectivity, exhibiting a Kb value of 2-3 nM in the urethra and prostate, compared to Kb values of 20-100 nM in the ear artery and aorta. Upidosin effectively inhibits [3H]prazosin binding to cloned human α-1A adrenergic receptors. This compound is a valuable tool for research focused on urethral obstruction and related conditions.
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