URB447 is a peripherally restricted antagonist of the CB1 receptor, exhibiting an IC50 of 313 nM for rat CB1 and 41 nM for human CB2 receptors. This compound effectively reduces food intake and body weight gain in murine models by circumventing the central nervous system, thereby not interfering with central CB1-mediated responses. URB447 serves as a valuable tool for obesity research, providing insights into the peripheral modulation of cannabinoid signaling.
URB447 is a peripherally restricted antagonist of the CB1 receptor, exhibiting an IC50 of 313 nM for rat CB1 and 41 nM for human CB2 receptors. This compound effectively reduces food intake and body weight gain in murine models by circumventing the central nervous system, thereby not interfering with central CB1-mediated responses. URB447 serves as a valuable tool for obesity research, providing insights into the peripheral modulation of cannabinoid signaling.
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