URMC-099

Catalog No.: A14219

MLK inhibitor

URMC-099

URMC-099 Chemical Structure

CAS NO. 1229582-33-5

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.

Availability: In stock

Package Price Qty
5 mg
$55.00
10 mg
$80.00
25 mg
$160.00
10mM * 1mL in DMSO
$70.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Elad Prinz, .et al. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis, Mol Biol Cell, 2018, Oct 1; 29(20): 2470-2480 PMID: 30091641

Biological Activity

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.
Targets
Target Value
Abl1IC50: 6.5nM
LRRK2IC50: 11nM
MLK3IC50: 14nM
MLK1IC50: 19nM
VEGFR1/FLT1IC50: 39nM
MLK2IC50: 42nM
SGKIC50: 67nM
TrkAIC50: 85nM
AuroraAIC50: 108nM
ROCK2IC50: 111nM
AuroraBIC50: 123nM
DLKIC50: 150nM
c-MetIC50: 177nM
IRIC50: 200nM
SGK1IC50: 201nM
TrkBIC50: 217nM
AuroraCIC50: 290nM
IGF-1RIC50: 307nM
LCKIC50: 333nM
MEKK2IC50: 661nM
SykIC50: 731nM
ROCK1IC50: 1030nM
CDK1IC50: 1125nM
CDK2IC50: 1180nM
AMPKIC50: 1512nM
JNK1IC50: 3280nM
SrcIC50: 4330nM
ZAP70IC50: 5050nM
ERK2IC50: 6290nM
GSK-3βIC50: >10000nM
p38αIC50: 12050nM
In vitro DMSO 76 mg/mL (180.28 mM)
Water Insoluble
Ethanol 5 mg/mL (11.86 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.72 mL 118.61 mL 237.23 mL
0.5 mM 4.74 mL 23.72 mL 47.45 mL
1 mM 2.37 mL 11.86 mL 23.72 mL
5 mM 0.47 mL 2.37 mL 4.74 mL

*The above data is based on the productmolecular weight 421.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14219
Actions Inhibitor
CAS No. 1229582-33-5
Formula C27H27N5
M. Wt 421.54
Purity >98%
Synonyms URMC 099,URMC099
SMILES CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy URMC-099 | URMC-099 Supplier | purchase | cost | manufacturer | order | distributor | buy 1229582-33-5| 1229582-33-5 Supplier | purchase 1229582-33-5 | 1229582-33-5 cost | 1229582-33-5 manufacturer | order 1229582-33-5 | 1229582-33-5 distributor
Rewards