URMC-099

Catalog No.: A14219
MLK inhibitor
URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.
Grouped product items
Product Name Price Stock Qty
URMC-099 5mg
$55.00
In stock
URMC-099 10mg
$80.00
In stock
URMC-099 25mg
$160.00
In stock
URMC-099 10mM * 1mL in DMSO
$70.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's URMC-099 has been cited by 1 publications
  • Elad Prinz, .et al. , Mol Biol Cell, 2018, Oct 1; 29(20): 2470-2480 PMID: 30091641
  • Biological Activity
    Discription URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively.
    Targets
    Target Value
    Product Information
    Catalog Num A14219
    Formula C27H27N5
    Molecular Weight 421.54
    CAS Number 1229582-33-5
    SMILES CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6
    Synonyms URMC 099,URMC099
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO 76 mg/mL (180.28 mM)
    Water Insoluble
    Ethanol 5 mg/mL (11.86 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.72 mL 118.61 mL 237.23 mL
    0.5 mM 4.74 mL 23.72 mL 47.45 mL
    1 mM 2.37 mL 11.86 mL 23.72 mL
    5 mM 0.47 mL 2.37 mL 4.74 mL
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    This equation is commonly abbreviated as: C1V1 = C2V2

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