Valecobulin

Catalog No.: A21242

β-tubulin polymerization inhibitor

Valecobulin

Valecobulin Chemical Structure

CAS NO. 1188371-47-2

Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.

Availability: In stock

Package Price Qty
5 mg
$315.00
10 mg
$543.00
50 mg
$1,610.00
100 mg
$3,220.00
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Biological Activity

Valecobulin (CKD516) is a valine prodrug of (S516) and a vascular disrupting agent (VDA). Valecobulin is a potent β-tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.64 mL 93.18 mL 186.36 mL
0.5 mM 3.73 mL 18.64 mL 37.27 mL
1 mM 1.86 mL 9.32 mL 18.64 mL
5 mM 0.37 mL 1.86 mL 3.73 mL

*The above data is based on the productmolecular weight 536.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21242
Actions Inhibitor
CAS No. 1188371-47-2
Formula C26H28N6O5S
M. Wt 536.6
Solubility DMSO
Purity >98%
Synonyms CKD-516
SMILES CC(C)[[email protected]](N)C(NC1=NC(C2=CC=C(C(C3=CC(OC)=C(OC)C(OC)=C3)=O)C(N4N=CN=C4)=C2)=CS1)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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