Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics.
Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics.
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