Vandetanib-d4 is a deuterium-labeled derivative of Vandetanib, a potent orally active inhibitor targeting VEGFR2/KDR tyrosine kinase with an IC50 of 40 nM. In addition to its primary action, Vandetanib exhibits inhibitory effects on VEGFR3/FLT4 and EGFR/HER1 with IC50 values of 110 nM and 500 nM, respectively. This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and elucidating the pharmacological pathways of tyrosine kinase inhibitors.
Vandetanib-d4 is a deuterium-labeled derivative of Vandetanib, a potent orally active inhibitor targeting VEGFR2/KDR tyrosine kinase with an IC50 of 40 nM. In addition to its primary action, Vandetanib exhibits inhibitory effects on VEGFR3/FLT4 and EGFR/HER1 with IC50 values of 110 nM and 500 nM, respectively. This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and elucidating the pharmacological pathways of tyrosine kinase inhibitors.
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