VGSC blocker-1 is a selective blocker of the neonatal voltage-gated sodium channel subtype Nav1.5 (nNav1.5). This small molecule inhibits peak sodium currents by 34.9% at a concentration of 1 μM, and it demonstrates a significant reduction in cell invasion by 0.3% at the same concentration in the MDA-MB-231 human breast cancer cell line, all while maintaining cell viability. VGSC blocker-1 is valuable for research into mechanisms of cancer metastasis and ion channel function in cellular processes.
VGSC blocker-1 is a selective blocker of the neonatal voltage-gated sodium channel subtype Nav1.5 (nNav1.5). This small molecule inhibits peak sodium currents by 34.9% at a concentration of 1 μM, and it demonstrates a significant reduction in cell invasion by 0.3% at the same concentration in the MDA-MB-231 human breast cancer cell line, all while maintaining cell viability. VGSC blocker-1 is valuable for research into mechanisms of cancer metastasis and ion channel function in cellular processes.
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