VH285-PEG4-C4-Cl is an E3 ligase ligand-linker conjugate that employs a halogenated connector within its 16-atom length linker. This compound combines the VH285-based VHL ligand with an alkyl/ether-based linker, demonstrating high efficacy as a degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl achieves approximately 90% degradation of GFP-HaloTag7 at a concentration of 625 nM and exhibits an IC50 value of 0.54 μM for binding to VHL. This compound is ideal for researchers investigating targeted protein degradation and E3 ligase interactions.
VH285-PEG4-C4-Cl is an E3 ligase ligand-linker conjugate that employs a halogenated connector within its 16-atom length linker. This compound combines the VH285-based VHL ligand with an alkyl/ether-based linker, demonstrating high efficacy as a degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl achieves approximately 90% degradation of GFP-HaloTag7 at a concentration of 625 nM and exhibits an IC50 value of 0.54 μM for binding to VHL. This compound is ideal for researchers investigating targeted protein degradation and E3 ligase interactions.
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