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- Tomohiro Nabekura, .et al. Effects of Antiviral Drugs on Organic Anion Transport in Human Placental BeWo Cells, Antimicrob Agents Chemother, 2015, Dec; 59(12): 7666-7670 PMID: 26416870
Biological Activity
Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52).
| In vitro | DMSO | 121 mg/mL (181.21 mM) | |
| Water | 34 mg/mL (50.92 mM) | ||
| Ethanol | 121 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.98 mL | 74.88 mL | 149.77 mL |
| 0.5 mM | 3 mL | 14.98 mL | 29.95 mL |
| 1 mM | 1.5 mL | 7.49 mL | 14.98 mL |
| 5 mM | 0.3 mL | 1.5 mL | 3 mL |
*The above data is based on the productmolecular weight 667.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10971 |
|---|---|
| Actions | Antagonist |
| CAS No. | 541503-81-5 |
| Formula | C28H38F3N5O2.C4H6O5 |
| M. Wt | 667.7 |
| Purity | >98% |
| SMILES | C[[email protected]]1CN(CCN1[[email protected]@H](COC)C2=CC=C(C=C2)C(F)(F)F)C3(CCN(CC3)C(=O)C4=C(N=CN=C4C)C)C.C(C(C(=O)O)O)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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