Fig. 1 · Structure
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Viltolarsen
Antisense Oligonucleotide
Viltolarsen is a phosphorodiamidate morpholino antisense oligonucleotide designed to target dystrophin mRNA by binding to exon 53. This mechanism promotes exon skipping, leading to the restoration of the open-reading frame and the production of a truncated dystrophin protein that preserves essential functional elements. Viltolarsen is primarily utilized in research related to Duchenne muscular dystrophy (DMD), making it a valuable tool for advancing therapeutic strategies in this condition.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2055732-84-6 |
| Applications | Antisense Oligonucleotide |
| Molecular Weight | 6924.80 |
| Synonyms | NS-065/NCNP-01 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.