Voacangine is a selective antagonist of the TRPM8 channel, competitively inhibiting the binding of menthol (IC50=9 μM) and noncompetitively inhibiting icilin (IC50=7 μM). It is known to block capsaicin binding to TRPV1 (IC50=50 μM) while exhibiting agonistic effects on TRPA1 (EC50=8 μM). Voacangine effectively antagonizes chemical agonist-induced activation of TRPM8, with no impact on cold-induced activation, making it a valuable tool for studying sensory signaling pathways. This alkaloid is derived from the root bark of Voacanga africana, providing a natural source for research applications.
Voacangine is a selective antagonist of the TRPM8 channel, competitively inhibiting the binding of menthol (IC50=9 μM) and noncompetitively inhibiting icilin (IC50=7 μM). It is known to block capsaicin binding to TRPV1 (IC50=50 μM) while exhibiting agonistic effects on TRPA1 (EC50=8 μM). Voacangine effectively antagonizes chemical agonist-induced activation of TRPM8, with no impact on cold-induced activation, making it a valuable tool for studying sensory signaling pathways. This alkaloid is derived from the root bark of Voacanga africana, providing a natural source for research applications.
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