VS3 is a selective inhibitor of the YAP-TEAD interaction, effectively disrupting their binding by targeting TEAD4 Interface 3 with a dissociation constant (Kd) of 6 μM. This compound demonstrates significant anti-proliferative effects in various cancer cell lines, including HT29, HCT116, and A2780. VS3 is a valuable tool for investigating signaling pathways in colorectal adenocarcinoma and ovarian cancer research.
VS3 is a selective inhibitor of the YAP-TEAD interaction, effectively disrupting their binding by targeting TEAD4 Interface 3 with a dissociation constant (Kd) of 6 μM. This compound demonstrates significant anti-proliferative effects in various cancer cell lines, including HT29, HCT116, and A2780. VS3 is a valuable tool for investigating signaling pathways in colorectal adenocarcinoma and ovarian cancer research.
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