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  1. YAP inhibitor

    Verteporfin is a small molecule that inhibits TEAD?€?YAP association and YAP-induced liver overgrowth. It is also a potent second-generation photosensitizing agent derived from porphyrin.
  2. Peptide 17 is a inhibitor of this YAP-TEAD protein-protein interaction which has potential usage in treatment of YAP-involved cancers with IC50 of 25nM.
  3. YAP1 inhibitor

    CIL56 is a YAP1 inhibitor.
  4. YAP/TAZ inhibitor

    YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 μμ in firefly luciferase assay.
  5. TEAD inhibitor

    MYF-01-37 is a novel covalent inhibitor of TEAD targeting Cys380.

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