VSP-77 is an orally active PPARγ agonist that enhances insulin sensitivity by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. This mechanism leads to the upregulation of key genes such as Glut4 and Adiponectin, which are crucial for glucose metabolism. In high-fat diet-induced diabetic mouse models, VSP-77 significantly improves glucose tolerance and lowers fasting blood glucose and insulin levels. It serves as a valuable reagent for studying diabetes and its associated metabolic pathways.
VSP-77 is an orally active PPARγ agonist that enhances insulin sensitivity by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. This mechanism leads to the upregulation of key genes such as Glut4 and Adiponectin, which are crucial for glucose metabolism. In high-fat diet-induced diabetic mouse models, VSP-77 significantly improves glucose tolerance and lowers fasting blood glucose and insulin levels. It serves as a valuable reagent for studying diabetes and its associated metabolic pathways.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
