VU0134992 hydrochloride is a selective blocker of the Kir4.1 potassium channel, exhibiting an IC50 of 0.97 µM. This compound demonstrates a nine-fold selectivity for homomeric Kir4.1 channels compared to Kir4.1/5.1 concatemeric channels, with an IC50 of 9 µM at -120 mV. Its unique profile makes it a valuable tool for investigating the physiological roles of Kir4.1 channels in various biological processes and potential therapeutic applications.
VU0134992 hydrochloride is a selective blocker of the Kir4.1 potassium channel, exhibiting an IC50 of 0.97 µM. This compound demonstrates a nine-fold selectivity for homomeric Kir4.1 channels compared to Kir4.1/5.1 concatemeric channels, with an IC50 of 9 µM at -120 mV. Its unique profile makes it a valuable tool for investigating the physiological roles of Kir4.1 channels in various biological processes and potential therapeutic applications.
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