VU0810464 is a potent and selective activator of G protein-gated inwardly rectifying potassium channels (GIRK, Kir3). It demonstrates nanomolar potency for neuronal GIRK channels (EC50=165 nM) and GIRK1/4 channels (EC50=720 nM), facilitating efficient modulation of neuronal excitability. The compound is particularly noteworthy for its enhanced brain penetration, making it a valuable tool for research focused on neuronal signaling and disorders involving GIRK channel dysfunction.
VU0810464 is a potent and selective activator of G protein-gated inwardly rectifying potassium channels (GIRK, Kir3). It demonstrates nanomolar potency for neuronal GIRK channels (EC50=165 nM) and GIRK1/4 channels (EC50=720 nM), facilitating efficient modulation of neuronal excitability. The compound is particularly noteworthy for its enhanced brain penetration, making it a valuable tool for research focused on neuronal signaling and disorders involving GIRK channel dysfunction.
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