VX-680 (MK-0457, Tozasertib)

Catalog No.: A10981
Aurora Kinase inhibitor
VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
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Product Name Price Stock Qty
VX-680 25mg
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VX-680 50mg
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VX-680 100mg
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VX-680 250mg
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VX-680 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's VX-680 (MK-0457, Tozasertib) has been cited by 2 publications
  • Sakamoto K, .et al. , Leukemia, 2018, May 23 PMID: 29795241
  • W. Joost Lesterhuis, .et al. , Sci Rep, 2015, 5: 12298 PMID: 26193793
  • Biological Activity
    Discription VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
    Target Value
    Product Information
    Catalog Num A10981
    Formula C23H28N8OS
    Molecular Weight 464.6
    CAS Number 639089-54-6

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO 90 mg/mL (193.71 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5% DMSO+30% PEG 300+2% Tween 80+ddH2O 14 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 21.52 mL 107.62 mL 215.24 mL
    0.5 mM 4.3 mL 21.52 mL 43.05 mL
    1 mM 2.15 mL 10.76 mL 21.52 mL
    5 mM 0.43 mL 2.15 mL 4.3 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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