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VX-680 (MK-0457, Tozasertib)

Catalog No.: A10981

Aurora Kinase inhibitor

VX-680 (MK-0457, Tozasertib)

VX-680 (MK-0457, Tozasertib) Chemical Structure

CAS NO. 639089-54-6

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Availability: In stock

Package Price Qty
25 mg
50 mg
100 mg
250 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Sakamoto K, .et al. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response, Leukemia, 2018, May 23 PMID: 29795241
  • W. Joost Lesterhuis, .et al. Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations, Sci Rep, 2015, 5: 12298 PMID: 26193793

Biological Activity

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
Aurora A (Cell-free assay) Aurora C (Cell-free assay) Aurora B (Cell-free assay) FLT3 (Cell-free assay) Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)4.6 nM(Ki app)18 nM(Ki app)30 nM(Ki)30 nM(Ki)
In vitro (25°C) DMSO 90 mg/mL (193.71 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+2% Tween 80+ddH2O 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.52 mL 107.62 mL 215.24 mL
0.5 mM 4.3 mL 21.52 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10981
Actions Inhibitor
CAS No. 639089-54-6
Formula C23H28N8OS
M. Wt 464.6
Purity >98%

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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