VX-680 (MK-0457, Tozasertib)

Name: VX-680 (MK-0457, Tozasertib)
Brand: Adooq Bioscience
SKU: A10981
Rating: 100 (2 reviews)

Catalog No.: A10981

Aurora Kinase inhibitor

Product Citations (2)

VX-680 (MK-0457, Tozasertib) Chemical Structure

CAS NO. 639089-54-6

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Availability: In stock

Package	Price	Qty
25 mg	$40.00
50 mg	$60.00
100 mg	$100.00
250 mg	$200.00
10mM * 1mL in DMSO	$60.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq VX-680 (MK-0457, Tozasertib)

Sakamoto K, .et al. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response, Leukemia, 2018, May 23 PMID: 29795241
W. Joost Lesterhuis, .et al. Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations, Sci Rep, 2015, 5: 12298 PMID: 26193793

Biological Activity

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Targets

Aurora A (Cell-free assay)	Aurora C (Cell-free assay)	Aurora B (Cell-free assay)	FLT3 (Cell-free assay)	Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)	4.6 nM(Ki app)	18 nM(Ki app)	30 nM(Ki)	30 nM(Ki)

Solubility *

In vitro (25°C)	DMSO	90 mg/mL (193.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+2% Tween 80+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.52 mL	107.62 mL	215.24 mL
0.5 mM	4.3 mL	21.52 mL	43.05 mL
1 mM	2.15 mL	10.76 mL	21.52 mL
5 mM	0.43 mL	2.15 mL	4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10981
Actions	Inhibitor
CAS No.	639089-54-6
Formula	C23H28N8OS
M. Wt	464.6
Purity	>98%
SMILES	CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.