VX-680 (MK-0457, Tozasertib)

Catalog No.: A10981

Aurora Kinase inhibitor

VX-680 (MK-0457, Tozasertib)

VX-680 (MK-0457, Tozasertib) Chemical Structure

CAS NO. 639089-54-6

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

Availability: In stock

Package Price Qty
25 mg

Regular Price: $40.00

Special Price $32.00

50 mg

Regular Price: $60.00

Special Price $48.00

100 mg

Regular Price: $100.00

Special Price $80.00

250 mg

Regular Price: $200.00

Special Price $160.00

10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
Targets
Aurora A (Cell-free assay) Aurora C (Cell-free assay) Aurora B (Cell-free assay) FLT3 (Cell-free assay) Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)4.6 nM(Ki app)18 nM(Ki app)30 nM(Ki)30 nM(Ki)
In vitro (25°C) DMSO 93 mg/mL (200.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.52 mL 107.62 mL 215.24 mL
0.5 mM 4.3 mL 21.52 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10981
Actions Inhibitor
M. Wt 464.6
Formula C23H28N8OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 639089-54-6
Synonyms N/A
SMILES CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5

Product Tags

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) Supplier | purchase VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) cost | VX-680 (MK-0457, Tozasertib) manufacturer | order VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) distributor | buy 639089-54-6| 639089-54-6 Supplier | purchase 639089-54-6 | 639089-54-6 cost | 639089-54-6 manufacturer | order 639089-54-6 | 639089-54-6 distributor
Rewards