Trusted by 10,000+ Scientists since 2006

VX-680 (MK-0457, Tozasertib)


Aurora Kinase inhibitor

0 Customer Reviews
Catalog No. A10981

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VX-680 25mg A10981-25

Regular Price: $40.00

Special Price: $36.00

VX-680 50mg A10981-50

Regular Price: $60.00

Special Price: $54.00

VX-680 100mg A10981-100

Regular Price: $100.00

Special Price: $90.00

VX-680 250mg A10981-250

Regular Price: $200.00

Special Price: $180.00

VX-680 10mM * 1mL in DMSO A10981-10mM-D

Regular Price: $60.00

Special Price: $54.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.

VX-680 (MK-0457, Tozasertib)

Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products
VX-680 (MK-0457, Tozasertib) Citations (2)
  • Sakamoto K, .et al. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response, Leukemia, 2018, May 23 PMID: 29795241
  • W. Joost Lesterhuis, .et al. Network analysis of immunotherapy-induced regressing tumours identifies novel synergistic drug combinations, Sci Rep, 2015, 5: 12298 PMID: 26193793

Chemical Information

Catalog Num A10981
Actions Inhibitor
M. Wt 464.6
Formula C23H28N8OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 639089-54-6
Synonyms N/A

Biological Activity

VX-680 is a potent and selective small-molecule inhibitor of the Aurora kinases.
Aurora A (Cell-free assay) Aurora C (Cell-free assay) Aurora B (Cell-free assay) FLT3 (Cell-free assay) Bcr-Abl (Cell-free assay)
0.6 nM(Ki app)4.6 nM(Ki app)18 nM(Ki app)30 nM(Ki)30 nM(Ki)


Solubility (25°C) * In vitro DMSO 93 mg/mL (200.17 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.52 mL 107.62 mL 215.24mL
0.5 mM 4.3 mL 21.52 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.52 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 464.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

View Related Products By Research Topics

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Other people marked this product with these tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Similar product(s)

Keywords:buy VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) Supplier | purchase VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) cost | VX-680 (MK-0457, Tozasertib) manufacturer | order VX-680 (MK-0457, Tozasertib) | VX-680 (MK-0457, Tozasertib) distributor | buy 639089-54-6| 639089-54-6 Supplier | purchase 639089-54-6 | 639089-54-6 cost | 639089-54-6 manufacturer | order 639089-54-6 | 639089-54-6 distributor