Biological Activity
VX-702 is an orally bioavailable inhibitor of p38 MAP kinase that inhibits platelet agonist induced p38 activation (IC50= 4 to 20 nM).
In vitro (25°C) | DMSO | 77 mg/mL (190.45 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 24.73 mL | 123.67 mL | 247.34 mL |
0.5 mM | 4.95 mL | 24.73 mL | 49.47 mL |
1 mM | 2.47 mL | 12.37 mL | 24.73 mL |
5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
*The above data is based on the productmolecular weight 404.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10982 |
---|---|
Actions | Inhibitor |
CAS No. | 479543-46-9, 745833-23-2 |
Formula | C19H12F4N4O2 |
M. Wt | 404.3 |
Purity | >98% |
Synonyms | VX702, VX 702 |
SMILES | C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
SB 203580
SB 203580 is a specific inhibitor of p38α and p38β which suppresses downstream activation of MAPKAP kinase-2 and heat shock protein 27.
Pamapimod (R-1503)
Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor.
Vinorelbine (Navelbine)
Vinorelbine is the first 5´NOR semi-synthetic vinca alkaloid. It is obtained by semi-synthesis from alkaloids extracted from the rosy periw…
SD-06
SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibi…
ML-3043
ML-3043 is a p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) a…
DBM 1285 dihydrochloride
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in viv…
PH-797804
PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
AMG 548
AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blo…
Keywords:buy VX-702 | VX-702 Supplier | purchase | cost | manufacturer | order | distributor | buy 479543-46-9, 745833-23-2| 479543-46-9, 745833-23-2 Supplier | purchase 479543-46-9, 745833-23-2 | 479543-46-9, 745833-23-2 cost | 479543-46-9, 745833-23-2 manufacturer | order 479543-46-9, 745833-23-2 | 479543-46-9, 745833-23-2 distributor