VX-765 (Belnacasan)

On Sale
Catalog No.: A10984
Caspase-1/4 inhibitor
VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
Grouped product items
Product Name Price Stock Qty
VX-765 5mg
Special Price $35.00 Regular Price $50.00
In stock
VX-765 10mg
Special Price $59.50 Regular Price $85.00
In stock
VX-765 50mg
Special Price $175.00 Regular Price $250.00
In stock
VX-765 100mg
Special Price $280.00 Regular Price $400.00
In stock
VX-765 10mM * 1mL in DMSO
Special Price $52.50 Regular Price $75.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's VX-765 (Belnacasan) has been cited by 8 publications
  • Joseph Flores, .et al. , Cell Death Dis, 2022, Oct 11;13(10):864 PMID: 36220815
  • Arjun Thapa, .et al. , Leukemia, 2021, 23 February
  • Prenitha Mercy Ignatius Arokia Doss, .et al. , Cell Rep, 2021, Mar 9;34(10):108833 PMID: 33691111
  • Joseph Flores, .et al. , Nat Commun, 2020, Sep 11;11(1):4571 PMID: 32917871
  • Joseph Flores, .et al. , Nat Commun, 2018, 9: 3916 PMID: 30254377
  • Mohamed F. Ali, .et al. , Front Immunol, 2017, 8: 1504 PMID: 29170665
  • García-Fernández A, .et al. , J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553
  • Jiujiu Yu, .et al. , Proc Natl Acad Sci U S A, 2014, 111(43): 15514-15519 PMID: 25313054
  • Biological Activity
    Discription VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
    Targets
    Target Value
    Product Information
    Catalog Num A10984
    Formula C24H33ClN4O6
    Molecular Weight 509
    CAS Number 273404-37-8
    SMILES CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
    Synonyms VX765
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO Warmed: 87 mg/mL (170.92 mM)
    Water Insoluble
    Ethanol Warmed: 87 mg/mL (170.92 mM)
    In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 19.65 mL 98.23 mL 196.46 mL
    0.5 mM 3.93 mL 19.65 mL 39.29 mL
    1 mM 1.96 mL 9.82 mL 19.65 mL
    5 mM 0.39 mL 1.96 mL 3.93 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy VX-765 (Belnacasan) | VX-765 (Belnacasan) Supplier | purchase VX-765 (Belnacasan) | VX-765 (Belnacasan) cost | VX-765 (Belnacasan) manufacturer | order VX-765 (Belnacasan) | VX-765 (Belnacasan) distributor | buy 273404-37-8 | 273404-37-8 Supplier | purchase 273404-37-8 | 273404-37-8 cost | 273404-37-8 manufacturer | order 273404-37-8 | 273404-37-8 distributor