VX-765 (Belnacasan)

Name: VX-765 (Belnacasan)
SKU: A10984
Price: 35 USD
Rating: 5 (8 reviews)

Catalog No.: A10984

Caspase-1/4 inhibitor

Adooq's VX-765 (Belnacasan) has been cited by 8 publications

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

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Grouped product items
Product Name	Price	Stock
VX-765 5mg	Special Price $35.00 Regular Price $50.00	In stock
VX-765 10mg	Special Price $59.50 Regular Price $85.00	In stock
VX-765 50mg	Special Price $175.00 Regular Price $250.00	In stock
VX-765 100mg	Special Price $280.00 Regular Price $400.00	In stock
*VX-765 10mM 1mL in DMSO**	Special Price $52.50 Regular Price $75.00	In stock
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Adooq Products cited in reputable paper

Adooq's VX-765 (Belnacasan) has been cited by 8 publications

Joseph Flores, .et al. , Cell Death Dis, 2022, Oct 11;13(10):864 PMID: 36220815

Arjun Thapa, .et al. , Leukemia, 2021, 23 February

Prenitha Mercy Ignatius Arokia Doss, .et al. , Cell Rep, 2021, Mar 9;34(10):108833 PMID: 33691111

Joseph Flores, .et al. , Nat Commun, 2020, Sep 11;11(1):4571 PMID: 32917871

Joseph Flores, .et al. , Nat Commun, 2018, 9: 3916 PMID: 30254377

Mohamed F. Ali, .et al. , Front Immunol, 2017, 8: 1504 PMID: 29170665

García-Fernández A, .et al. , J Control Release, 2017, Feb 28;248:60-70 PMID: 28069553

Jiujiu Yu, .et al. , Proc Natl Acad Sci U S A, 2014, 111(43): 15514-15519 PMID: 25313054

Biological Activity

Discription

VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.

Targets

Target	Value

Product Information

Catalog Num	A10984
Formula	C24H33ClN4O6
Molecular Weight	509
CAS Number	273404-37-8
SMILES	CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl
Synonyms	VX765
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 87 mg/mL (170.92 mM)
	Water	Insoluble
	Ethanol	Warmed: 87 mg/mL (170.92 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.65 mL	98.23 mL	196.46 mL
0.5 mM	3.93 mL	19.65 mL	39.29 mL
1 mM	1.96 mL	9.82 mL	19.65 mL
5 mM	0.39 mL	1.96 mL	3.93 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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