VX-770 (Ivacaftor)

Catalog No.: A10985

CFTR activator

VX-770 (Ivacaftor) Chemical Structure

CAS NO. 873054-44-5, 121911-71-5

VX-770 (Ivacaftor) is known as a CFTR potentiator.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$120.00
50 mg
$380.00
100 mg
$650.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

VX-770 (Ivacaftor) is known as a CFTR potentiator.
Targets
F508del-CFTR (Fisher rat thyroid cells) G551D-CFTR (Fisher rat thyroid cells)
25 nM(EC50)100 nM(EC50)
In vitro DMSO 78 mg/mL (198.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.39 mL 254.78 mL
0.5 mM 5.1 mL 25.48 mL 50.96 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10985
Actions Activator
M. Wt 392.5
Formula C24H28N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 873054-44-5, 121911-71-5
Synonyms Kalydeco, VX770
SMILES CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C

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