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$0.00 - Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157
Biological Activity
VX-770 (Ivacaftor) is known as a CFTR potentiator.
Targets
| F508del-CFTR (Fisher rat thyroid cells) | G551D-CFTR (Fisher rat thyroid cells) | |||
| 25 nM(EC50) | 100 nM(EC50) |
| In vitro | DMSO | 69 mg/mL (175.8 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.48 mL | 127.39 mL | 254.78 mL |
| 0.5 mM | 5.1 mL | 25.48 mL | 50.96 mL |
| 1 mM | 2.55 mL | 12.74 mL | 25.48 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10985 |
|---|---|
| Actions | Activator |
| CAS No. | 873054-44-5, 121911-71-5 |
| Formula | C24H28N2O3 |
| M. Wt | 392.5 |
| Purity | >98% |
| Synonyms | Kalydeco, VX770 |
| SMILES | CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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