VX-770 (Ivacaftor)

Catalog No.: A10985

CFTR activator

VX-770 (Ivacaftor)

VX-770 (Ivacaftor) Chemical Structure

CAS NO. 873054-44-5, 121911-71-5

VX-770 (Ivacaftor) is known as a CFTR potentiator.

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Okiyoneda T, .et al. Chaperone-Independent Peripheral Quality Control of CFTR by RFFL E3 Ligase, Dev Cell, 2018, Mar 26;44(6):694-708.e7 PMID: 29503157

Biological Activity

VX-770 (Ivacaftor) is known as a CFTR potentiator.
F508del-CFTR (Fisher rat thyroid cells) G551D-CFTR (Fisher rat thyroid cells)
25 nM(EC50)100 nM(EC50)
In vitro DMSO 69 mg/mL (175.8 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.48 mL 127.39 mL 254.78 mL
0.5 mM 5.1 mL 25.48 mL 50.96 mL
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL

*The above data is based on the productmolecular weight 392.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10985
Actions Activator
CAS No. 873054-44-5, 121911-71-5
Formula C24H28N2O3
M. Wt 392.5
Purity >98%
Synonyms Kalydeco, VX770

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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