WCA-814 is a conjugate that functions as an androgen receptor (AR) antagonist and Hsp90 inhibitor. This compound effectively induces degradation of full-length androgen receptors as well as the AR-V7 variant. WCA-814 demonstrates notable cytotoxicity in prostate cancer cells, with an IC50 of 171.2 nM, and 26.5 nM and 22 nM for LNCaP and 22Rv1 cell lines, respectively. This makes it a valuable tool for research in prostate cancer therapeutics and underlying mechanisms of androgen receptor signaling.
WCA-814 is a conjugate that functions as an androgen receptor (AR) antagonist and Hsp90 inhibitor. This compound effectively induces degradation of full-length androgen receptors as well as the AR-V7 variant. WCA-814 demonstrates notable cytotoxicity in prostate cancer cells, with an IC50 of 171.2 nM, and 26.5 nM and 22 nM for LNCaP and 22Rv1 cell lines, respectively. This makes it a valuable tool for research in prostate cancer therapeutics and underlying mechanisms of androgen receptor signaling.
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