WHI-P 154

Name: WHI-P 154
Brand: Adooq Bioscience
SKU: A14049
Rating: 100 (268 reviews)

Catalog No.: A14049

JAK3 inhibitor

WHI-P 154 Chemical Structure

CAS NO. 211555-04-3

WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro.

Availability: In stock

Package	Price	Qty
10 mg	$80.00
25 mg	$160.00
50 mg	$300.00
10mM * 1mL in DMSO	$85.00
Custom Size	Get quote

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Biological Activity

WHI-P 154 is a JAK3 inhibitor with IC50 = 1.8uM. WHI-P 154 also Inhibits STAT1 activation, iNOS expression and NO production in macrophages in vitro.

Targets

EGFR	VEGFR	Src	JAK3
4 nM	100 nM	100 nM	1.8 μM

Solubility *

In vitro (25°C)	DMSO	74 mg/mL (196.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.58 mL	132.91 mL	265.82 mL
0.5 mM	5.32 mL	26.58 mL	53.16 mL
1 mM	2.66 mL	13.29 mL	26.58 mL
5 mM	0.53 mL	2.66 mL	5.32 mL

*The above data is based on the productmolecular weight 376.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A14049
Actions	Inhibitor
CAS No.	211555-04-3
Formula	C16H14BrN3O3
M. Wt	376.2
Purity	>98%
Synonyms	WHI-P154
SMILES	COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.