Catalog No.: A16205

pan-WNK-kinase inhibitor


WNK463 Chemical Structure

CAS NO. 2012607-27-9

WNK463 is an orally bioavailable pan-WNK-kinase inhibitor.

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  • Lu DC, .et al. The role of WNK in modulation of KCl cotransport activity in red cells from normal individuals and patients with sickle cell anaemia, Pflugers Arch, 2019, Dec;471(11-12):1539-1549 PMID: 31729557

Biological Activity

WNK463 is an orally bioavailable pan-WNK-kinase inhibitor.
In vitro (25°C) DMSO 81 mg/mL (174.77 mM)
Water Insoluble
Ethanol 81 mg/mL (174.77 mM)
In vivo 5% DMSO+30%PEG 300+5% Tween 80+ddH2O 7 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.58 mL 107.88 mL 215.77 mL
0.5 mM 4.32 mL 21.58 mL 43.15 mL
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 463.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16205
Actions Inhibitor
CAS No. 2012607-27-9
Formula C21H24F3N7O2
M. Wt 463.46
Purity >98%
Synonyms WNK-463, WNK 463

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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