Wnt-C59

Catalog No.: A12951

PORCN/Wnt inhibitor

Wnt-C59

Wnt-C59 Chemical Structure

CAS NO. 1243243-89-1

Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$85.00
25 mg
$150.00
50 mg
$250.00
10mM * 1mL in DMSO
$80.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Laksitorini MD, .et al. Modulation of Wnt/β-catenin signaling promotes blood-brain barrier phenotype in cultured brain endothelial cells, Sci Rep, 2019, Dec 23;9(1):19718 PMID: 31873116

Biological Activity

Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
Targets
Porcn (HEK293 cells )
74 pM
In vitro (25°C) DMSO 76 mg/mL (200.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.35 mL 131.77 mL 263.54 mL
0.5 mM 5.27 mL 26.35 mL 52.71 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12951
Actions Inhibitor
M. Wt 379.45
Formula C25H21N3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1243243-89-1
Synonyms WntC59
SMILES CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4

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