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WP1066

Catalog No.: A11795

JAK Inhibitor

WP1066

WP1066 Chemical Structure

CAS NO. 857064-38-1

WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.

Availability: In stock

Package Price Qty
10 mg
$60.00
25 mg
$140.00
50 mg
$210.00
10mM * 1mL in DMSO
$70.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476

Biological Activity

WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
Targets
JAK2 (HEL cells) STAT3 (HEL cells)
2.3 μM2.43 μM
In vitro DMSO 64 mg/mL (179.66 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.07 mL 140.37 mL 280.74 mL
0.5 mM 5.61 mL 28.07 mL 56.15 mL
1 mM 2.81 mL 14.04 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11795
Actions Inhibitor
CAS No. 857064-38-1
Formula C17H14BrN3O
M. Wt 356.2
Purity >98%
Synonyms WP 1066, WP-1066
SMILES C[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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