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- Simona Moravcova, .et al. The Circadian Rhythms of STAT3 in the Rat Pineal Gland and Its Involvement in Arylalkylamine-N-Acetyltransferase Regulation, Life (Basel), 2021, Oct 18;11(10):1105 PMID: 34685476
Biological Activity
WP1066 is a novel JAK2 inhibitor and it suppresses proliferation and induces apoptosis in eythroid human cells carrying the JAK2 V617F mutation.
Targets
| JAK2 (HEL cells) | STAT3 (HEL cells) | |||
| 2.3 μM | 2.43 μM |
| In vitro | DMSO | 64 mg/mL (179.66 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.07 mL | 140.37 mL | 280.74 mL |
| 0.5 mM | 5.61 mL | 28.07 mL | 56.15 mL |
| 1 mM | 2.81 mL | 14.04 mL | 28.07 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
*The above data is based on the productmolecular weight 356.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11795 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 857064-38-1 |
| Formula | C17H14BrN3O |
| M. Wt | 356.2 |
| Purity | >98% |
| Synonyms | WP 1066, WP-1066 |
| SMILES | C[[email protected]@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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