XL01126

Name: XL01126
Brand: Adooq Bioscience
SKU: A23936
Rating: 5 (288 reviews)

Catalog No.: A23936

LRRK2 PROTAC

XL01126 is a potent PROTAC degrader of LRRK2, with DC₅₀ values of 14 nM for the G2019S mutant and 32 nM for wild-type LRRK2. It is blood-brain barrier permeable, making it a valuable tool for Parkinson’s disease research. XL01126 enables investigation of both catalytic and non-catalytic functions of LRRK2.

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Grouped product items
Size	Price	Stock
1mg	$558.00	In stock
5mg	$1,480.00	In stock
10mg	$2,280.00	In stock
50mg	$6,800.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	XL01126 is a potent PROTAC degrader of LRRK2, with DC₅₀ values of 14 nM for the G2019S mutant and 32 nM for wild-type LRRK2. It is blood-brain barrier permeable, making it a valuable tool for Parkinson’s disease research. XL01126 enables investigation of both catalytic and non-catalytic functions of LRRK2.

Product Information

Catalog Num	A23936
Formula	C50H64ClFN10O6S2
Molecular Weight	1019.69
CAS Number	3011029-58-3
SMILES	O=C([C@H]1N(C([C@@H](NC(C2(F)CC2)=O)C(C)(SC[C@@H]3CC[C@@H](CN4CCN(C(C5=CC=C(NC6=NC=C(Cl)C(NC)=N6)C(OC)=C5)=O)CC4)CC3)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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