Catalog No.: A12394

JAK2 inhibitor


XL019 Chemical Structure

CAS NO. 945755-56-6

XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.

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5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $150.00

Special Price $120.00

25 mg

Regular Price: $250.00

Special Price $200.00

100 mg

Regular Price: $750.00

Special Price $600.00

10mM * 1mL in DMSO

Regular Price: $139.00

Special Price $111.20

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Biological Activity

XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.
Target Value
JAK2IC50: 2.2nM
PDGFRβIC50: 125.4nM
JAK1IC50: 134.3nM
FLT3IC50: 139.7nM
JAK3IC50: 214.2nM
c-KitIC50: 225.8nM
p70S6KIC50: 313.8nM
TYK2IC50: 348.3nM
MLK1IC50: 370.0nM
IKKβIC50: 375.4nM
KDRIC50: 483.6nM
PDGFRαIC50: 546.7nM
FLT4IC50: 554.5nM
FLT1IC50: 910.5nM
In vitro DMSO 14 mg/mL (31.49 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.5 mL 112.48 mL 224.96 mL
0.5 mM 4.5 mL 22.5 mL 44.99 mL
1 mM 2.25 mL 11.25 mL 22.5 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12394
Actions Inhibitor
CAS No. 945755-56-6
Formula C25H28N6O2
M. Wt 444.53
Purity >98%
Synonyms XL 019, XL-019
SMILES C1C[[email protected]](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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