Trusted by 10,000+ Scientists since 2006



JAK2 inhibitor

0 Customer Reviews
Catalog No. A12394

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL019 5mg A12394-5

Regular Price: $90.00

Special Price: $81.00

XL019 10mg A12394-10

Regular Price: $150.00

Special Price: $135.00

XL019 25mg A12394-25

Regular Price: $250.00

Special Price: $225.00

XL019 100mg A12394-100

Regular Price: $750.00

Special Price: $675.00

XL019 10mM * 1mL in DMSO A12394-10mM-D

Regular Price: $139.00

Special Price: $125.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.


Double click on above image to view full picture

Zoom Out
Zoom In

More Views

Publications citing Adooq Products

Chemical Information

Catalog Num A12394
Actions Inhibitor
M. Wt 444.53
Formula C25H28N6O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945755-56-6
Synonyms XL 019, XL-019
SMILES C1C[[email protected]](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5

Biological Activity

XL019 is an orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity.
Target Value
JAK2IC50: 2.2nM
PDGFRβIC50: 125.4nM
JAK1IC50: 134.3nM
FLT3IC50: 139.7nM
JAK3IC50: 214.2nM
c-KitIC50: 225.8nM
p70S6KIC50: 313.8nM
TYK2IC50: 348.3nM
MLK1IC50: 370.0nM
IKKβIC50: 375.4nM
KDRIC50: 483.6nM
PDGFRαIC50: 546.7nM
FLT4IC50: 554.5nM
FLT1IC50: 910.5nM


Solubility (25°C)* In vitro DMSO 16 mg/mL (35.99 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.5 mL 112.48 mL 224.96mL
0.5 mM 4.5 mL 22.5 mL 44.99 mL
1 mM 2.25 mL 11.25 mL 22.5 mL
5 mM 0.45 mL 2.25 mL 4.5 mL

*The above data is based on the productmolecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Keywords:buy XL019 | XL019 Supplier | purchase XL019 | XL019 cost | XL019 manufacturer | order XL019 | XL019 distributor | buy 945755-56-6| 945755-56-6 Supplier | purchase 945755-56-6 | 945755-56-6 cost | 945755-56-6 manufacturer | order 945755-56-6 | 945755-56-6 distributor