XL765

Catalog No.: A10997

PI3K inhibitor

XL765

XL765 Chemical Structure

CAS NO. 1349796-36-6

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $90.00

Special Price $81.00

10 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $450.00

Special Price $405.00

100 mg

Regular Price: $750.00

Special Price $675.00

10mM * 1mL in DMSO

Regular Price: $167.00

Special Price $150.30

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Targets
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM
In vitro (25°C) DMSO 12 mg/mL (20.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.68 mL 83.38 mL 166.75 mL
0.5 mM 3.34 mL 16.68 mL 33.35 mL
1 mM 1.67 mL 8.34 mL 16.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A10997
Actions Inhibitor
M. Wt 599.7
Formula C31H29N5O6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1349796-36-6
Synonyms XL-765
SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC

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