Biological Activity
XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Targets
Target | Value |
---|---|
PI3Kγ | IC50: 9nM |
PI3Kα | IC50: 39nM |
PI3Kδ | IC50: 43nM |
PI3Kβ | IC50: 113nM |
DNA-PK | IC50: 150nM |
mTOR | IC50: 157nM |
In vitro (25°C) | DMSO | 10 mg/mL (16.68 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 16.68 mL | 83.38 mL | 166.75 mL |
0.5 mM | 3.34 mL | 16.68 mL | 33.35 mL |
1 mM | 1.67 mL | 8.34 mL | 16.68 mL |
5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10997 |
---|---|
Actions | Inhibitor |
CAS No. | 1349796-36-6 |
Formula | C31H29N5O6S |
M. Wt | 599.7 |
Purity | >98% |
Synonyms | XL-765 |
SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC3=NC4=CC=CC=C4N=C3NC5=CC(=CC(=C5)OC)OC)OC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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