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PI3K inhibitor

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Catalog No. A10997

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
XL765 5mg A10997-5

Regular Price: €85.50

Special Price: €76.95

XL765 10mg A10997-10

Regular Price: €152.00

Special Price: €136.80

XL765 50mg A10997-50

Regular Price: €427.50

Special Price: €384.75

XL765 100mg A10997-100

Regular Price: €712.50

Special Price: €641.25

XL765 10mM * 1mL in DMSO A10997-10mM-D

Regular Price: €158.65

Special Price: €142.79

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.


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Chemical Information

Catalog Num A10997
Actions Inhibitor
M. Wt 599.7
Formula C31H29N5O6S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1349796-36-6
Synonyms XL-765

Biological Activity

XL765 is a PI3K/mTOR dual kinase inhibitor and it is more potent compared to an agent that inhibits either PI3K kinase or mTOR kinase alone.
Target Value
PI3KγIC50: 9nM
PI3KαIC50: 39nM
PI3KδIC50: 43nM
PI3KβIC50: 113nM
DNA-PKIC50: 150nM
mTORIC50: 157nM


Solubility (25°C) * In vitro DMSO 12 mg/mL (20.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.68 mL 83.38 mL 166.75mL
0.5 mM 3.34 mL 16.68 mL 33.35 mL
1 mM 1.67 mL 8.34 mL 16.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL

*The above data is based on the productmolecular weight 599.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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