Y-29794 is a selective, orally active inhibitor of non-peptide prolyl endopeptidase (PREP), demonstrating an IC50 of 3 nM and a Ki of 0.95 nM. It enhances the efficacy of thyrotropin-releasing hormone (TRH) on acetylcholine release in the rat hippocampus, indicating potential neuroprotective effects. Additionally, Y-29794 exhibits anticancer activity by inhibiting the IRS1-AKT-mTORC1 signaling pathway and shows the capability to penetrate the blood-brain barrier (BBB), making it valuable for various neurological and oncology research applications.
Y-29794 is a selective, orally active inhibitor of non-peptide prolyl endopeptidase (PREP), demonstrating an IC50 of 3 nM and a Ki of 0.95 nM. It enhances the efficacy of thyrotropin-releasing hormone (TRH) on acetylcholine release in the rat hippocampus, indicating potential neuroprotective effects. Additionally, Y-29794 exhibits anticancer activity by inhibiting the IRS1-AKT-mTORC1 signaling pathway and shows the capability to penetrate the blood-brain barrier (BBB), making it valuable for various neurological and oncology research applications.
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